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In TRIUMPH-1, full average weight loss outcomes were reached at 80 weeks (just over 18 months), with continued reductions seen in some patients at 104 weeks

Persistent or severe reflux warrants clinical review, since reports show about 15% experienced reflux symptoms in some series and among certain GI cohorts 10 out of 50 patients developed severe reflux oesophagitis

For example, nuclear p53 and FOXOs promote ATG expression, whereas cytoplasmic p53 and ATF5 act as autophagy repressors in certain contexts

From a purely pharmacological perspective, these agents operate independently

Some people may report fewer side effects after switching to a different GLP-1

Reiss AB, Gulkarov S, Lau R, Klek SP, Srivastava A, Renna HA, et al