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People with gastrointestinal issues or pernicious anemia should take a one-milligram dose of B12 daily, in either injection or oral forms

It should not be bought online or used outside an authorised clinical trial

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Other risk groups include older adults, pregnant women, people taking metformin or long-term acid-suppressing medications (PPIs, H2 blockers), those with conditions affecting the gastrointestinal tract (pernicious anaemia, Crohn's disease, coeliac disease), and individuals who have undergone gastric or ileal surgery

The European Food Safety Authority (EFSA) has set an adequate intake (AI) of 4.0 g/day for adults (EFSA, 2015)

Because TB-500 distributes systemically regardless of injection site, there is no clinical requirement to inject near the injury