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At the same time, tissue inhibitors of metalloproteinases (TIMPs) increase across all tested concentrations

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Therefore, a meta-defencor targeting mitochondria has been developed, which scavenges mtROS and suppresses mitochondrial nitric oxide synthase, thereby increasing mitochondrial transcription factor A expression, restoring aerobic respiration, and reprogramming mitochondrial metabolism for the conversion of M1 macrophages to M2 macrophages (135)

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