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A decrease in glutathione also happens due to environmental and lifestyle factors such as stress etc

doi: 10.4049/jimmunol.1701010 164 RothAGustafsonPNhagaARDjanaQPoulsenAGarlyMLet al

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In fact, treatment with the bacterium Akkermansia muciniphila diminished the inducement of a depression-like behavior caused by chronic stress, where the regulation of this metabolic profile stands on such variables as acute corticosterone, dopamine, and BDNF (Ding et al., 2021)

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Potential mechanisms identified underlying this include an increase in the risk factors for both uric acid and calcium oxalate kidney stones