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It requires daily dosing, compared to weekly dosing for semaglutide and tirzepatide

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Peart MJ, Tainton KM, Ruefli AA, Dear AE, Sedelies KA, O'Reilly LA et al

It is increasingly discussed in longevity and preventive-medicine circles as a way to achieve: Metabolic balance without extreme appetite suppression Sustained tolerability by avoiding gastrointestinal side effects Lower cost and simplified maintenance regimens Long-term receptor engagement for cardiometabolic and neuroprotective benefits While this approach remains off-label and under formal investigation, the biological rationale is strong: GLP-1 signaling is not binary but dose-responsive, and even partial activation may influence inflammatory, vascular, and cognitive pathways linked to aging