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This represents approximately 3-fold improved local delivery and demonstrates that formulation significantly impacts outcomes

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The neurotoxicity of IFN- is well established (298), as well as the cognitive impairment induced by this cytokine (299)

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In terms of LDL-C lowering, rosuvastatin has proven most effective, whilst pravastatin and simvastatin are better for increasing HDL-C, and atorvastatin in reducing triglyceride levels [31, 32] (Figure 1)