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High dose oral supplementation is an effective alternative to parenteral treatment Randomized studies of daily high oral doses of 1,0002,000 g have shown equivalence or superiority to injected B 12

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These results constituted an important proof of concept for the use of long-acting GHRH analogs

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The most robust clinical evidence to date concerns the improvement of muscular and metabolic parameters (strength, endurance, insulin sensitivity) and the modulation of chronic inflammation. A 2024 randomised trial comparing NAD IV with NR IV in healthy adults showed that both modalities increase the available NAD pool, with a favourable safety profile

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