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Four, resmetirom confers significant advantages to patient cohorts who do not meet the indication of GLP-1 therapies, including individuals who have already attained weight reduction and populations not afflicted with diabetes

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Results do vary between individuals, and treatment should be reviewed at 12 weeks if less than 5% weight loss has been achieved at the full 3 mg dose

In addition, GLP-1 also exerts actions independent of insulin secretion, such as inhibiting glucagon secretion, gastric emptying, and gastric acid secretion while reducing food intake after both intracerebroventricular and peripheral administration [8]

This contributes to reduced appetite, increased feeling of fullness, and delayed gastric emptying

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