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MS is a major social health problem, particularly in developed nations such as the United States but also in Europe, with a prevalence of 20 and 30%, respectively (33)
Even though the immune system responds towards inflammatory stimuli through ROS, increased ROS levels can damage DNA, proteins, and lipids, and result in activating various signaling pathways (such as NF-B and mitogen-activated protein kinase (MAPK)), stimulating T helper cells 1 (Th1) and Th17 cells, and promoting the release of inflammatory cytokines (Plenkowska et al., 2020), which can contribute to the development and exacerbation of the psoriatic inflammation
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Thus, we hypothesize that the water molecule can act as a possible nucleophile to attack the H-site bound GSH and generate GS