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This opens the prospect of integrative approaches combining pharmacotherapy with microbiome modulation and establishes a foundation for novel strategies, such as genetically engineered probiotics capable of locally producing GLP-1 in the intestine

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Jaganjac M et al

Introduction Obesity and overweight have grown to epidemic proportions resulting in more than 4 million individuals dying/year in 2017, according to the Global Burden of Disease Study [1]

Cu, ZnSOD protects the vascular and immune systems from the harmful effects of ROS