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Hormonal systems also interact with medication tolerance in ways that are often overlooked

173(9):694703 Veerman JL, Barendregt JJ, Forster M, Vos T (2011) Cost-effectiveness of pharmacotherapy to reduce obesity

While not first-line therapies, both drug classes show promise as adjuncts in high-risk populations

P = 0.32) 28 and leptin (1.67 [2.64, 0.70]

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As a GIP/GLP-1 receptor agonist, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying