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In the TRIUMPH-4 trial , published by Eli Lilly in December 2025, participants taking the 12 mg dose lost an average of 28.7% of their body weight at 68 weeks , and WOMAC pain scores were reduced significantly

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They also reported that sulforaphane decreased the protein expression of DNA methytransferases (DNMTs) and histone deacetylase (HDAC) 1/2/3/4

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