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They conclude: "These results may help veterinarians apply the results of the EPIC Trial to dogs with preclinical MMVD when an echocardiogram is not readily available." Imagine that
The intrinsically disordered interdomain region between the helicase and nuclease domains of an archaeal Hef protein from Thermococcus kodakarensis was shown to be involved in interactions with multiple proteins including PCNA1 and a RecJ-like protein, suggesting that Hef acts as a scaffold and uses this IDR for sequential interaction with several proteins to control the repair pathway at the stalled fork (Ishino et al., 2014)
CPT-11-Taxotere-5-FU Regimen for Induction and Concurrent Chemoradiotherapy Prior to Surgery in Patients with Resectable Esophageal or GEJ Carcinoma
At 1,000 mg delivered intravenously, plasma concentrations reach 30 to 70 times higher than what oral dosing can achieve