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doi:10.1038/nrneurol.2017.185 17

However, previous studies have not investigated GLP-1 analogs and exendin 939 for pain transmission at peripheral sites, especially in small-sized nociceptive DRG neurons, where the TRPV1 channel is crucial in chronic pain-induced mechanical allodynia and thermal hyperalgesia 58,59,60,61

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Preclinical studies have also pointed out that AMPK activates SIRT1 by up-regulating the NAD+ levels, which in turn promotes the deacetylation of SIRT1 and activates PGC-1, thereby forming the AMPK-SIRT1-PGC-1 signaling axis

doi: 10.4252/wjsc.v16.i6.690 143 JacksonMVMorrisonTJDohertyDFMcAuleyDFMatthayMAKissenpfennigAet al