Semaglutide administration led to a decrease in BMD: 2.1% in the lumbar spine ( p = 0.01), 2.6% in the total hip ( p = 0.001), and 1.5% in the tibial volumetric BMD ( p = 0.003)
This warning extends to all medicines in these classes approved for diabetes and/or chronic weight management, including: semaglutide ( Ozempic , Wegovy ) dulaglutide ( Trulicity ) liraglutide ( Victoza, Saxenda ) tirzepatide ( Mounjaro )
Additionally, understanding your personal genetic predispositions through the PlexusDx Precision Peptide Genetic Test can reinforce motivation to stay consistentknowing whether genetic variants in your GLP1R, GIPR, or FTO pathways influence your weight and appetite response may increase your commitment to steady dosing
You may want to discuss with your healthcare team how different meal plans and long-term changes in eating style can help you better manage your diabetes and possibly help with your personal weight goals
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10.1016/s0958-1669(00)00199-3 55 UribeP