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Inflammopharmacology 14 , 214221

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The first statin discovered was mevastatin, which was isolated from a fungus by Akira Endo in the 1970s ( FIGURE 1 To date, the only Food and Drug Administration (FDA)approved route of administration for statins is oral (Korani et al., 2019)

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Subsequently, 4-hydroxyproline was found to be an abundant constituent of collagen and elastin