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The increasing prevalence of obesity in T1DM is concurrently a consequence of a combination of variables, including genetic susceptibility to insulin resistance, the influence of an obesogenic environment, a sedentary lifestyle, as well as the impact of numerous biological, psychological and social stressors [18, 23]

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For frozen sections, 4% paraformaldehyde-fixed brains were mildly shaken in 20% sucrose solution for 6 h and then 30% sucrose solution overnight at 4 C

N-3, particularly EPA and DHA, and its derivatives reduce oxidative stress and inflammation, and decrease cell death in several pathological conditions (33, 70, 71) through different mechanisms closely related to microglial activity

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In the late 19th century, Hugo Schulz observed that low concentrations of disinfectants could stimulate yeast metabolism, a finding initially dismissed as experimental error due to the prevailing scientific paradigm 5