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Hsiao et al., 2008)

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Glucose is transported into intestinal L-cells by sodium-glucose cotransporters, and the resultant increase in Ca 2+ influx triggers GLP-1 secretion 32

This is the first study to show a clear benefit of GLP-1 receptor agonists on kidney failure or end-stage kidney disease, suggesting they have a key role in kidney-protective and heart-protective treatment for patients with common medical conditions like type 2 diabetes, overweight or obesity with cardiovascular disease, or CKD, he said