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Summarised studies Safety profile Across published rodent toxicology, Epitalon has been administered at doses dramatically exceeding the proposed pharmacological range without acute organ toxicity, mutagenic findings or evidence of tumour-promoting activity

PLoS One 8:e54794

World Health Organization (2023) World malaria report 2023

At higher maintenance doses, the B12 delivery increases accordingly

Methionine is then converted into S-adenosylmethionine (SAM), which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine (SAH) that is converted back into homocysteine