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It is noteworthy that these findings are similar to those of several rat studies, evidencing in the case of the BPC 157 therapy a consistent transfer of animal data [180,265,266,267,268]
Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S
In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)
