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Peoples JN, Saraf A, Ghazal N, Pham TT, Kwong JQ

Under normal physiological conditions, most of the iron exists in hemoglobin, and other Fe 3+ combines with transferrin (TF) to form transferrin-bound iron (TBI) (46)

Redifferentiation of dedifferentiated human chondrocytes in high-density cultures

The interactions between these organ injuries trigger MODS [67,68,69,70]

In diabetic state, hyperglycemia leads to overproduction of free radicals (i.e., mitochondrial , NO and peroxynitrite) mainly derived from glucose oxidation and lipid peroxidation, which cause oxidative damage to biomolecules