Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound)
Ginger tea specifically has evidence supporting its anti-nausea effects and can be a useful tool during dose transitions
Clozapine directly increases insulin and glucagon secretion from islets: implications for impairment of glucose tolerance
But searching everywhere, eventually people started looking at CRP C-reactive protein and then things started to roll in the direction of the immune system, of the inflammatory and anti-inflammatory actions of the compounds
Second, the gap between tirzepatide and retatrutide (approximately 6 percentage points) is smaller than the gap between semaglutide and tirzepatide (approximately 7-8 percentage points), which means the incremental benefit of adding glucagon agonism is real but not proportionally larger than the benefit of adding GIP
doi: 10.1016/J.JDIACOMP.2024.108834 101 VarnumAAPozziEDeebelNAEvansAEidNSadeghi-NejadHet al