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The emergence of pancreatitis in this population raises questions about whether the drugs risk-benefit profile was appropriately communicated and whether additional warnings should have been implemented as prescribing patterns shifted

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The manuscript is critically revised by XG and finally approved by all authors for publication

Skin cancer was not identified in a study of 30 individuals with OCA4.[90] Of note, a meta-analysis demonstrated that the SLC45A2 p.Phe374Leu variant was protective for melanoma, with an OR of 0.41 (95% CI, 0.330.50

This configuration supports planned treatment series, consultation-to-procedure scheduling, and cart restocking for clinics that maintain defined mesotherapy protocols