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NO is involved in normal cell signaling, contributing to the regulation of various physiological functions [141, 142] including activation of soluble guanylyl cyclase (sGC) which generates cyclic GMP (cGMP) [143]

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Case and control subject selection Cases in the study cohort were defined as patients who experienced incident NAFLD/NASH events during follow-up after cohort entry (i.e., GLA initiation)