Gastroenterology | ACG
In a randomized clinical trial in women with breast cancer, it was found that rosuvastatin prevented the development of chemotherapy-induced cardiotoxicity [83]
DNA methyltransferase 1-mediated modifications exhibit bidirectional effects: hypermethylation of promoter regions in protective genes, such as ACTN4 (encoding -actinin-4), suppresses their expression, while hypomethylation of pro-pathogenic genes, including matrix metalloproteinase-9, enhances their transcription (67, 68)
Currently, PPI drugs that have been approved for clinical use are mainly divided into small-molecule drugs and biologics (including proteins and antibodies), for example, navitoclax and its analogs that prevent the interaction between B-cell lymphoma-2 (BCL-2) and proapoptotic proteins BCL-2 homologs antagonist/killer (BAK) and BCL-2-associated X-protein (BAX) [5] and the antibody trastuzumab that are used to block the human epidermal growth factor receptor-2 (HER2) receptor [6]
A second potentially involved mechanism underlying l-ARG effects on PSV at dynamic PDU might concern l-ARG effect on testosterone levels
Sulphur-rich veggies: Garlic, onion, and cruciferous vegetables (like broccoli or cabbage) boost glutathione enzymes
