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These changes create NDP--MSH (Nle4, D-Phe7--MSH), which is approximately 100-1000 times more potent than native -MSH at the MC1R receptor and is resistant to enzymatic degradation

Finding evidence of diffuse vascular insufficiency on the brain scan of an older patient is so common that it is often read as normal for age. Consequently, healthcare practitioners often tell such patients that their scan was normal. However, when this finding occurs in a patient who is having symptoms that could be associated with vascular insufficiency, the situation and the brain scan should be re-evaluated

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Less Common but Serious Side Effects: Sudden severe pelvic pain or bloating

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