doi: 10.1038/nm1272
The combination of dropping estrogen, the decline in physical activity that tends to happen as you age, and side effects of menopause like trouble sleeping all combine for a slow-and-steady weight gain
Actin dynamics refers to processes that control cell shape, movement, and internal organization
I was dealing with a lot of hair loss
To meet the diagnostic criteria for aEDS, a person must meet: Major criterion 1 AND major criterion 3 OR Major criterion 1 AND major criterion 2 and at least two minor criteria Major Criteria Congenital bilateral hip dislocation Severe generalized joint hypermobility, with multiple dislocations/subluxations Skin hyperextensibility Minor Criteria Muscle hypotonia Kyphoscoliosis Radiologically mild osteopenia Tissue fragility, including atrophic scars Easily bruisable skin Diagnostic Criteria To meet the diagnostic criteria for BCS, a person must meet: Major criterion 1 AND at least one other major criterion OR Major criterion 1 AND at least three minor criteria Major Criteria Thin cornea, with or without rupture (central corneal thickness often +2 Feature B: Positive family history (one or more first-degree relatives independently meet the current diagnostic criteria for hEDS) Feature C: Musculoskeletal complications (must have at least one of the following): Musculoskeletal pain in two or more limbs, recurring daily for at least three (3) months Chronic, widespread pain for at least three (3) months Recurrent joint dislocations or frank joint instability, in the absence of trauma (a or b) Three (3) or more atraumatic dislocations in the same joint or two (2) or more atraumatic dislocations in two (2) different joints occurring at different times OR Medical confirmation of joint instability at two (2) or more sites not related to trauma Criterion 3: ALL of the following prerequisites must be met: Absence of unusual skin fragility, which should prompt consideration of other types of EDS Exclusion of other heritable and acquired connective tissue disorders, including autoimmune rheumatologic conditions In patients with an acquired connective tissue disorder (e.g., lupus, rheumatoid arthritis, etc.), additional diagnosis of hEDS requires meeting both Features A and B of Criterion 2
both remain in clinical development and should only be accessed through regulated clinical trial settings
