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Copper complexes, such as the Hinokitiol copper complex, inhibit the deubiquitinase activity of certain proteasomes, contributing to ATF4-associated ER stress and subsequently to paraptosis [147]
Animal acute toxicity studies across Sikiric's group publications have consistently shown a low acute toxicity profile, with no defined lethal dose identified in standard rodent models
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7.3 Development of combined intervention strategies The revised section now discusses the potential of combined therapeutic approaches, such as the co-administration of natural bioactive compounds with probiotics or prebiotics, to synergistically regulate gut microbiota composition, restore intestinal barrier integrity, and reduce hepatic oxidative stress and inflammation
Ferroptosis in viral infection: the unexplored possibility
