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The phase III REDEFINE 1 study results, released in December 2024, showed that the CagriSema treatment group lost 22.7% of their weight after 68 weeks, significantly outperforming the single-target control drugs (semaglutide group lost 16.1%, cagrilintide group lost 11.8%)

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These molecules create a state of chronic low-grade inflammation that causes fatigue, brain fog, muscle aches, and reduced motivation