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Whilst extremely rare, anaphylaxis to B12 preparations has been documented

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By activating GIP receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia

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Chemically speaking, it is a saturated (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life