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These outcomes resulted in the authors saying more research is needed into the possible carcinogenic effects of GLP-1 drugs, such as Wegovy

Dosing and Administration Typical dose : 12 mg via subcutaneous injection Onset : Begins within 3060 minutes of administration Duration of action : 612 hours (individual variability may apply) Injection sites : Abdomen, thigh, or other subcutaneous regions Note : Do not exceed one dose in 24 hours

doi: 10.1038/nrm.2016.25 15 AebersoldRMannM

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CYP3A4 activity, however, showed no correlation to Tac parent/metabolite ratios, confirming CYP3A5 as the single most important determinant of Tac metabolism (54)

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