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Many in vivo studies involving cyclophosphamide-induced interstitial cystitis have confirmed these findings

Modulation of inflammatory processes by regulating cytokine activity and reducing excessive tissue fibrosis

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With the rise of Arabidopsis as a study system, and notably genome sequencing, the pathway and its genes were characterized at the molecular genetic level, revealing (or confirming) that all four enzymes were encoded by more than one gene, thus explaining the presence of the enzyme activities in several compartments (Table 1)