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Neurology 42 , 12091214 (1992)

Most patients experience a noticeable slowdown in weight loss around week 1220 of treatment, particularly if they've already lost 1015% of their starting weight

An individualised riskbenefit discussion with a specialist is appropriate for anyone in this group who may be considered for treatment in future

That structural gap is one reason the evidence base looks the way it does

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I've seen a ton of patients in my clinic that actually did have insurance coverage and were paying $200, $300 a month for compounded products when nobody mentioned to them that they should check with their insurance