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By activating GLP-1 receptors in the hypothalamus and other brain regions involved in satiety, semaglutide reduces hunger signals and enhances the feeling of satisfaction after eating smaller amounts of food

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A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

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Its essential oil relaxes GI smooth muscles and inhibits intestinal spasms

Endocr Pract 4(2):8285