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Although occasionally linked to irritability or agitation, mechanistic investigations also suggest LEV can mitigate neuroinflammation, for instance, by suppressing transcription factors and restoring astrocytic gap junction coupling, potentially contributing to improved affect regulation (Kim et al., 2010

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Genetics Varying gene mutations and polymorphisms can impact folate transport into the cell and brain

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The indazole group was identified as essential for maintaining the compound's hydrogen-bonding interactions with ECL2 residues

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