Any of these requires deferral to the FAA
The underlying mechanisms have not been fully delineated but are likely to involve modulation of the brain dopamine reward system via GLP-1 receptors, which are present both in the ventral tegmental areas (VTA), where dopamine neurons are located, and in the nucleus accumbens (NAc), which is the main projection of VTA dopamine neurons 14
05:28 Thu, Jul 23 20263:52 AM EDT
Oxyntomodulin is a biased agonist relative to GLP-1 1, 3 (and exendin-P5 26 ), with bias towards arrestin recruitment over cAMP production, which would compete for G protein interactions and may contribute to the lack of correlation between the faster G s dissociation and enhanced efficacy when assessing cAMP accumulation in whole cells over an extended timeframe
It is a close structural analogue of the naturallyoccurring GHK-Cu (Copper Tripeptide1), differing only in a single Nterminal residue: alanine in place of glycine (one methyl group)
J.YangY
