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In vivo rodent models have explored the pharmacokinetics and tissue distribution of Proxofim, examining whether the protease-resistant DRI backbone achieves sufficient systemic exposure and tissue penetration

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The conversion rate was calculated as follows: Results and discussion Sample preparation of the conversion SIDA method The sample preparation of the conversion SIDA method was developed and optimized aiming at achieving complete conversions of all native cobalamins into the cyano-form, a prerequisite for accurate quantification of total B12 as CNCbl

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