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As a noteworthy finding, the effector domain is the most distinctive feature of NLR proteins and serves as the basis for their classification into five subfamilies: NLRA, NLRB, NLRC, NLRP, and NLRX (58)

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and Shneider, N.A

Among them rs1801133(C677T) and rs1801131(A1298C) are most reported that may reduce the MTHFR activity in various degrees

PMID: 26174307 DOI: 10.1093/bja/aev103 Trujillo R, West WP (2022): Pseudocholinesterase deficiency

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