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Other experts believe the drug may cause a drop in blood pressure by helping people lose weight quickly or by affecting fluid levels in the body

Finally, the finding of statistically significantly greater weight reduction for tirzepatide versus semaglutide is further supported by a cohort study which found a greater average 1-year weight reduction for tirzepatide versus semaglutide based on real-world evidence [24]

Were endotoxins evaluated where relevant

Tirzepatide has also been associated with increased heart rate in some patients

They share overlapping incretin effects, so combining them may increase gastrointestinal side effects without clear evidence of added benefit

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