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Plus, it has a slight effect on the release of adrenocorticotrophic hormone (ACTH), prolactin and cortisol
The combined activity at two complementary pathways is the leading hypothesis for why tirzepatide tends to produce larger effects on weight and glycemic control in trials
The 26-week pivotal trial enrolled 412 participants with HIV-associated abdominal lipohypertrophy (Falutz et al., PMID 18057338)
Maintaining or increasing physical activity during tapering is also criticalstudies show people who exercise during discontinuation retain 4060% more of their weight loss than sedentary peers
Potential Side Effects and Risks Both semaglutide and tirzepatide are generally well-tolerated, but like any medication, they can cause side effects
A doctor or pharmacist can help assess risks, benefits, and appropriate dosing
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