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Analysts project that within five years, annual spending on GLP-1 obesity drugs could exceed $100 billion

doi: 10.1023/A:1018863716749 160 SchirraJHouckPWankUArnoldRGkeBKatschinskiM

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GLP-1RA (such as exendin-4) treatment can reduce the size of MI impacted cardiac volume in rats, inhibit ventricular dilation, myocardial fibrosis and hypertrophy in vivo [72]

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These mechanisms result in the downregulation of Bcl-2 and NF-B p65, alongside the upregulation of cleaved caspase-3/8 and Bax, ultimately inducing apoptosis in ovarian cancer cells [68]