Evidence and Research Comparison# Melanotan-1 Research# Melanotan-1 has one of the strongest clinical evidence bases among peptides studied for photoprotection: Phase 3 RCTs in EPP : Two pivotal randomized, double-blind, placebo-controlled trials demonstrated clinical efficacy
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September 2013
Maiorino, M
The Modern Problem: Light Deprivation In modern societies, several trends are reducing our exposure to natural sunlight: More time spent indoors Widespread use of LED lights, which emit no infrared light Low-E glass in buildings blocks beneficial wavelengths A new Department of Energy ruling (set for 2028) may further restrict the sale of bulbs with any infrared component due to energy efficiency requirements
Patients with MDD exhibit KP dysregulation, often marked by an overproduction of quinolinic acid, an N-Methyl-D-aspartic acid receptor (NMDAR) agonist that drives excitotoxicity, alongside reduced production of kynurenic acid, an NMDAR antagonist that protects from excitotoxicity and has anti-inflammatory effects
