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Enhancing mitophagy in such cells (experimentally via PINK1 overexpression) could reduce ROS and inflammasome activity, highlighting the tight link between mitochondrial quality control and immune cell inflammatory status (65)

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We also discuss their regulatory roles in the biosynthesis of secondary metabolites, such as glucosinolates, flavonoids, terpenoids, lignans, and astragalosides

Crystallogr.) , 59(12): 2072-2082

Abnormal iron metabolism is a significant trigger for ferroptosis, with iron-related proteins including transferrin receptor protein 1 (TfR1), ferritin (FTH and FTL), and iron export proteins playing essential roles in iron homeostasis