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The production of significant lactate by tumor cells is due to glycolysis, which serves as an intermediary between tumor cells and TAMs, thereby enhancing M2-like polarization through hypoxia-inducible factor 1 (HIF1) [64]

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The theoretical rationale is strong, supported by decades of immunology research demonstrating its Th1/Treg-promoting effects and the well-established Th2 dominance of eczema

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Jia W, Rajani C, Kaddurah-Daouk R, Li H

If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized