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It acts directly on the pancreas augmenting glucose-stimulated insulin secretion (148)

The observed interactions between the ECD and ECL1/3 in the inactive GLP-1R structure presented here agree with previous studies suggesting that the ECD stabilized an inactive state of the glucagon receptor through interactions with ECL1 and ECL3 20

7a), y = 0.0165 x + 0.1362 ( R 2 = 0.999) (Fig

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