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a , A concentration of ~75 mM inorganic P i ions in solution induces a complete movement of the NTD in apo p97-ND1L into the down position

On this basis, this review systematically summarizes the pharmacokinetic evidence and biological basis of long-term in vivo accumulation of platinum-based chemotherapeutic agents, elaborates on the mechanisms of organ toxicity mediated by platinum accumulation, clarifies the core association between insufficient platinum accumulation in tumor cells and chemoresistance, and finally concludes the key challenges and future research directions in this field, aiming to provide a theoretical basis for individualized adjustment of clinical chemotherapy regimens, early screening and intervention of long-term toxicity caused by platinum accumulation, and long-term health management of cancer survivors

19 Always consult a healthcare professional before introducing supplements, as they may interact with medications or existing conditions