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While analysis of additional cryo-EM data and PDBePISA interface analysis support a potential ASK1 Sh MAX2 dimer, several lines of evidenceincluding lack of conservation across orthologues, condition-dependent dimer formation, and absence of dimers in rice D3 crystal structuresargue against a conserved or functionally relevant dimer (Supplementary Discussion, Supplementary Fig

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Further study is encouraging for the perspective utilization of CR-associated mechanisms in clinical oncology strategies

Two compounds

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For oral capsules, the answer is a resounding and definitive no