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Valproic acid enhances CAR-T cell recognition of tumor targets and cytotoxic effects by upregulating the expression of NKG2D ligands (ULBP1-3) on tumor cell surfaces and activating the NKG2D-NKG2DL immune recognition axis (71)

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Additionally, breakthroughs in gene therapy and gene-cell combined therapy are promising for the large-scale clinical application of NADs

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L-ascorbic acid is the form of vitamin C that is naturally produced by mammals in their livers, and studies have shown that it has higher bioavailability compared to sodium ascorbate

[DOI] [PubMed] [Google Scholar] 36.Oey NA, van Vlies N, Wijburg FA, Wanders RJ, Attie-Bitach T, Vaz FM