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Huntly BJ, Gilliland DG

A large 2022 trial that monitored digestive side effects found a median duration of constipation of 47 days in people on semaglutide, compared with 35 days on placebo, suggesting the effect often persists for weeks during dose escalation and early maintenance

Vasoactive intestinal peptide stimulates melanogenesis in B16F10 mouse melanoma cells via CREB/MITF/tyrosinase signaling

This effect contributes to its potential neuroprotective and cardioprotective benefits

The THI was significantly greater ( p 0.05)

Another meta-analysis, which looked at relevant data from multiple clinical studies, estimated that 40-70% of people on GLP-1 drugs will experience nausea at some point while taking the medication