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Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of MTC or MEN2), and warnings regarding pancreatitis, gallbladder disease, and severe gastrointestinal disease

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Moreover, a detail mechanism can be performed using QM/MM simulation to understand the proton transfer during oxidation of selected flavonoids when interacting through A-ring and B-ring in the presence of blocked or free 3-OH group on the unconjugated C-ring with catechol group